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KMID : 1039220150250030254
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Journal of Korean Society of Occupational and Environmental Hygiene
2015 Volume.25 No. 3 p.254 ~ p.284
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Selection of Target Materials for GLP Genotoxic Tests by Searching the Mutagenicity Information of Chemicals by Occupational Safety and Health Act
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Rim Kyung-Taek
Lim Cheol-Hong
Ahn Byung-Joon
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Abstract
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Objectives: There is a requirement to select target materials for mutagenicity(Genotoxicity) testing, so we determined to set the test priorities of them by searching the related database.
Methods and Results: We searched a number of databases to find information on mutagenicity tests with chemicals under the Occupational Safety and Health Act(OSH Act), such as KOSHANET, National Toxicology Program(NTP), European Chemicals Agency(ECHA), US National Library of Medicine(NLM), and Genetic Toxicology Data Bank(GENE-TOX), as well as ChemIDplus webpage, and presented the information. Also we anticipated their hazards with ACToR sites to confirm the 58 mutagenicity(Genotoxicity) tests we will perform.
Conclusions: We presented target materials for mutagenicity testing with specific GLP tests consisting of reverse mutation(Ames), chromosomal aberration and micronucleus test.
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KEYWORD
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Candidate materials, genotoxic, GLP, mutagenicity, Occupational Safety and Health Act
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